Intestinal Oxidative State Can Alter Nutrient and Drug Bioavailability
نویسندگان
چکیده
منابع مشابه
Intestinal oxidative state can alter nutrient and drug bioavailability
Organic cations (OCs) are substances of endogenous (e.g. dopamine, choline) or exogenous (e.g. drugs like cimetidine) origin that are positively charged at physiological pH. Since many of these compounds can not pass the cell membrane freely, their transport in our out of cells must be mediated by specific transport systems. Transport by organic cation transporters (OCTs) can be regulated rapid...
متن کاملNutrient Effects on Intestinal Drug Absorption*
The effect of oral co-administration of nutrients on intestinal drug absorption is a function of drug dissolution, gastrointestinal (GI) residence time and intestinal membrane transport. Nutrient effects on GI residence time may influence the availability of the drug for absorption when dissolution is rate controlling; alternatively, nutrient effects on membrane transport pathways may dictate v...
متن کاملPlants may alter competition by modifying nutrient bioavailability in rhizosphere: a modeling approach.
Plants modify nutrient availability by releasing chemicals in the rhizosphere. This change in availability induced by roots (bioavailability) is known to improve nutrient uptake by individual plants releasing such compounds. Can this bioavailability alter plant competition for nutrients and under what conditions? To address these questions, we have developed a model of nutrient competition betw...
متن کاملAcute Heat Stress and Reduced Nutrient Intake Alter Intestinal Proteomic Profile and Gene Expression in Pigs
Heat stress and reduced feed intake negatively affect intestinal integrity and barrier function. Our objective was to compare ileum protein profiles of pigs subjected to 12 hours of HS, thermal neutral ad libitum feed intake, or pair-fed to heat stress feed intake under thermal neutral conditions (pair-fed thermal neutral). 2D-Differential In Gel Electrophoresis and gene expression were perform...
متن کاملSuccinobucol's new coat--conjugation with steroids to alter its drug effect and bioavailability.
Synthesis, detailed structural characterization (X-ray, NMR, MS, IR, elemental analysis), and studies of toxicity, antioxidant activity and bioavailability of unique potent anti-atherosclerotic succinobucol-steroid conjugates are reported. The conjugates consist of, on one side, the therapeutically important drug succinobucol ([4-{2,6-di-tert-butyl-4-[(1-{[3-tert-butyl-4-hydroxy-5-(propan-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2009
ISSN: 1942-0900,1942-0994
DOI: 10.4161/oxim.2.5.9769